10

New Cancer Drug Delivery System Is Effective And Reversible

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

For cancer drug developers, finding an agent that kills tumor cells is only part of the equation. The drug must also spare healthy cells, and – ideally – its effects will be reversible, to cut short any potentially dangerous side effects.

9

Genomic Signature In Blood Identifies Underlying Viral Infection

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

Scientists have identified a genomic "signature" in circulating blood that reveals exposure to common upper respiratory viruses, like the cold or flu, even before symptoms appear.

9

Gene Transcribing Machine Takes Halting, Backsliding Trip Along The DNA

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

The body's nanomachines that read our genes don't run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists

10

Colon Cancer May Yield To Cellular Sugar Starvation

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

Scientists at the Johns Hopkins Kimmel Cancer Center have discovered how two cancer-promoting genes enhance a tumor’s capacity to grow and survive under conditions where normal cells die. The knowledge, they say, may offer new treatments that starve cancer cells of a key nutrient - sugar. However, the scientists caution that research does not suggest that altering dietary sugar will make any difference in the growth and development of cancer.

9

Doubts over stem cell images prompt new inquiry

sea-maid submitted, created time 5 years 4 months (www.newscientist.com)

LIGHTNING never strikes again in the same place? Tell that to the University of Minnesota in Minneapolis, which has launched yet another inquiry into research at its Stem Cell Institute after New Scientist raised further concerns about papers that seem to contain duplicated and manipulated images.

9

'Green' energy from algae

sea-maid submitted, created time 5 years 4 months (www.eurekalert.org)

KIT 'algae platform' develops efficient photoreactors and novel cell decomposition methods

9

Bladder cells feel stretch

sea-maid submitted, created time 5 years 4 months (www.eurekalert.org)

Bladder is known to release ATP that activates micturition reflex pathway during urine storage. However, it has been unknown how urothelial cells sense bladder distension. The research group examined the function of 'TRPV4' protein abundantly expressed in urothelial cells. The group developed a special apparatus to measure cell responses upon stretch stimulation, which mimics bladder distension.

7

Sensitizing tumor response to cancer therapy

sea-maid submitted, created time 5 years 4 months (www.eurekalert.org)

Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.

8

Gut Hormone Has 'Remote Control' On Blood Sugar

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

A gut hormone first described in 1928 plays an unanticipated and important role in the remote control of blood sugar production in the liver, according to a report in the August 6th Cell Metabolism, a Cell Press publication. What's more, the researchers show that rats fed a high-fat diet for a few days become resistant to the glucose-lowering hormone known as cholecystokinin (CCK).

9

New Insights Into Health And Environmental Effects Of Carbon Nanoparticles

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

A new study raises the possibility that flies and other insects that encounter nanomaterial "hot spots," or spills, near manufacturing facilities in the future could pick up and transport nanoparticles on their bodies, transferring the particles to other flies or habitats in the environment.

8

PROTOTROPIC TAUTOMERISM IN AQUEOUS SOLUTION

venchev submitted, created time 5 years 4 months (www.discover8.com)

The tautomeric equilibria of formamide, thioformamide, selenoformamide, 2-amino-4-oxo-oxazoline, 2-amino-4-oxo-thiazoline and 5-fluorouracil are studied in gas phase and in water solution using post-Hartree-Fock (MPn) and DFT quantum chemical calculations. The values of the proton transfer barriers in isolated, mono- and polyhydrated tautomers of the studied compounds are calculated for two different mechanisms of tautomerisation. It is inferred that in the absence of water, the process of proton transfer should not occur

8

antitumor activity of platinum(II) complexes of 3-aminocyclohexanespiro-5-hydantoin

venchev submitted, created time 5 years 4 months (www.discover8.com)

New platinum(II) complexes of 3-aminocyclohexanespiro-5-hydantoin (achsh) were prepared and characterized. Ab initio calculation of the structure and the measurements of IR and NMR spectra of [Pt(NH 3)(achsh)Cl2 ] were also performed. Quantum-chemical and spectroscopic studies indicated a cis-square planar structure with a hydantoin ligand coordinated via the NH2 group. The complexes were evaluated for in vitro cytotoxicity in murine erythroleukemia (MEL) cells, clone F4N, as well as for in vivo antitumor activity toward murine L1210 leukemia

7

Treatment Options Equally Effective, Likelihood Of Success Known Early On

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

Results of a long-awaited study of 3,070 American adults at Johns Hopkins and 118 other U.S. medical centers show that treatment with either of the two standard antiviral drug therapies is safe and offers the best way for people infected with hepatitis C to prevent liver scarring, organ failure and death.

7

Ovarian cancer early warning hope as 'killer' gene discovered

sea-maid submitted, created time 5 years 4 months (www.dailymail.co.uk)

Scientists have pinpointed a common genetic flaw behind ovarian cancer - raising hopes of earlier diagnosis of the devastating condition.

7

Heavy Drinkers Face Significantly Increased Cancer Risk

sea-maid submitted, created time 5 years 4 months (www.sciencedaily.com)

Heavy drinkers of beer and spirits face a much higher risk of developing cancer than the population at large, says a group of Montreal epidemiologists and cancer researchers. Their findings show that people in the highest consumption category increased their risk of developing oesophageal cancer sevenfold, colon cancer by 80% and even lung cancer by 50%.

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