A 25-Signal Proteomic Signature and Outcome for Patients With Resected Non–Small-Cell Lung Cancer

claudia submitted, created time 1 year 6 months (jnci.oxfordjournals.org)

Among patients with non–small-cell lung cancer (NSCLC), those with poor prognosis cannot be distinguished from those with good prognosis. Matrix-assisted laser desorption–ionization mass spectrometry was used to analyze protein profiles of 174 specimens from NSCLC tumors and 27 specimens from normal lung tissue and to derive a prognosis-associated proteomic signature. Frozen resected tissue specimens were randomly divided into a training set (116 NSCLC and 20 normal lung specimens) and an independent, blinded validation set (58 NSCLC and seven normal lung specimens). We defined a mass spectrometry signature that was associated with survival among NSCLC patients and appeared to distinguish those with poor prognosis from those with good prognosis.

Keywords: Non–Small-Cell Lung Cancer Proteomic Signature