A search for biomarkers for early detection of colorectal cancer

william submitted, created time 1 year 1 month (www.eurekalert.org)

Using two-dimensional gel electrophoresis, 27 differentially expressed proteins were identified in colorectal adenoma, compared with individual-matched normal mucosa and cancer tissue. In those proteins, the differential expression of two novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validated by Western-blot. This study clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer.

Keywords: biomarker detect colorectal cancer protein