Acetylation Is Indispensable for p53 Activation

kavin submitted, created time 6 months 3 days (www.cell.com)

The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished. This study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response.

Keywords: p53 Mdm2 p53 activation acetylation