digiview submitted, created time 1 year 11 months (biology.plosjournals.org)

Using transgenic mice in which hepatocyte clocks can be turned on and off at will, this study suggest that 90% of the circadian transcription program in the liver is abolished or strongly attenuated when hepatocyte clocks are turned off. The remaining 10% of cyclically expressed liver genes continue to be transcribed in a robustly circadian fashion in the absence of functional hepatocyte oscillators. These 10% genes must therefore be regulated by oscillating systemic signals, such as hormones, metabolites, or body temperature.

Keywords: circadian clock liver circadian gene circadian oscillators mPer2 Per2 HSF BMAL1