Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

Our data provide new insight into the mechanism by which n-3 PUFA suppress tumorigenesis through dampening of inflammation and NF-B activity. These results support a protective role of n-3 PUFA supplementation in the prevention of colorectal cancer.

Keywords: n-3 fatty acids inflammation colorectal cancer tumorigenesis fat-1 transgenic mice