Compensatory Evolution in Response to a Novel RNA Polymerase: Orthologous Replacement of a Central Network Gene

alpha submitted, created time 1 year 9 months (mbe.oxfordjournals.org)

"Surprisingly, the T7 genome adapted to T3 RNAP also maintained high fitness when using T7 RNAP, suggesting that the extreme incompatibility of T7 elements with T3 RNAP is not an invariant property of divergence in these expression systems."

Keywords: experimental evolution bacteriophage genomics adaptation