jerry submitted, created time 6 months 3 weeks (www.genesdev.org)

Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.

Keywords: cancer bone cancer Rb p53 Osteosarcoma