Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway

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Fanconi anemia (FA) is a genome instability syndrome that is characterized by progressive bone marrow failure and a high risk of cancer. FA patients are particularly susceptible to leukemia as well as squamous cell carcinomas (SCCs) of the head and neck, anogenital region and skin. This article details experiments exploring the up and downregulation of FA.

Keywords: squamous cell carcinoma leukemia cancer bone marrow anemia Fanconi anemia