DNA Damage Signals for p53 Pulses

jerry submitted, created time 6 months 8 hours (www.sciencedirect.com)

A major challenge of systems biology is to understand how network topology affects protein dynamics in living cells. A new study show that p53 pulses are driven by pulses in the upstream signaling kinases, ATM and Chk2, and that a negative feedback mediated by the phosphatase Wip1 is essential for maintaining the uniform shape of p53 pulses.

Keywords: Chk2 Wip1 ATM cell signaling kinases protein dynamics DNA Damage p53