Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

davis submitted, created time 1 year 2 months (www.pnas.org)

When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, at least in vitro.

Keywords: dendrites cell signaling nervous system viral antigens vaccines preactivation dendritic cells