Dietary Fat and Postmenopausal Invasive Breast Cancer in the National Institutes of Health–AARP Diet and Health Study Cohort

daphne submitted, created time 1 year 9 months (jnci.oxfordjournals.org)

“Although ecologic association and animal studies support a direct effect of dietary fat on the development of breast cancer, results of epidemiologic studies have been inconclusive. We prospectively analyzed the association between fat consumption and the incidence of postmenopausal invasive breast cancer in the National Institutes of Health–AARP Diet and Health Study, a US cohort comprising 188 736 postmenopausal women who completed a 124-item food-frequency questionnaire in 1995–1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models with adjustment for energy and potential confounding factors. All statistical tests were two-sided. In this large prospective cohort with a wide range of fat intake, dietary fat intake was directly associated with the risk of postmenopausal invasive breast cancer.”

Keywords: breast cancer dietary fat