Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

davidd submitted, created time 10 months 2 days (www.nature.com)

Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.

Keywords: multidrug resistance polymorphisms breast cancer cancer drug delivery drug transporters BCRP