Familial Alzheimer's disease mutations alter the stability of the amyloid β-protein monomer folding nucleus

sumsung submitted, created time 1 year 1 month (www.pnas.org)

Amyloid β-protein (Aβ) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD). Recently, to elucidate the oligomerization pathway, we studied Aβ monomer folding and identified a decapeptide segment of Aβ.

Keywords: Amyloid β -protein neurotoxin Alzheimers disease familial disease