Influenza A Virus Neuraminidase Limits Viral Superinfection

sea-maid submitted, created time 6 months 1 week (jvi.asm.org)

Enveloped viruses use multiple mechanisms to inhibit infection of a target cell by more than one virion. These mechanisms may be of particular importance for the evolution of segmented viruses, because superinfection exclusion may limit the frequency of reassortment of viral genes.

In this study, the author shows that cellular expression of influenza A virus neuraminidase (NA), but not hemagglutinin (HA) or the M2 proton pump, inhibits entry of HA-pseudotyped retroviruses. Cells infected with H1N1 or H3N2 influenza A virus were similarly refractory to HA-mediated infection and to superinfection with a second influenza A virus.

Keywords: viruses superinfection enveloped viruses M2 proton pump hemagglutinin virus neuraminidase influenza influenza virus