jerry submitted, created time 6 months 1 week (www.developmentalcell.com)

Surprisingly, sensitive-to-resistant transition happened in post-stage-12 embryos when they are irradiated.

The magic key of this is in the irradiation-responsive enhancer regions of the proapoptotic genes. It becomes enriched for trimethylated H3K27/H3K9 and forms a heterochromatin-like structure during the sensitive-to-resistant transition.

Keywords: apoptosis H3K27/H3K9 H3K27 H3K9 irradiation radiation gene expression proapoptosis transition embryos