Leptin and Amylin Agonism: a Hope for Diet-induced Obesity

davidd submitted, created time 5 months 4 weeks (www.pnas.org)

Body weight is regulated by complex neurohormonal interactions between endocrine signals of long-term adiposity (e.g., leptin, a hypothalamic signal) and short-term satiety (e.g., amylin, a hindbrain signal). Leptin has been placed too much hope on weight loss. It became a failure for weight loss in non-leptin-deficient, diet-induced obese (DIO) rodents and humans. Today, we have some good news for for the obese. This study reports that concurrent peripheral administration of amylin and leptin elicits synergistic, fat-specific weight loss in leptin-resistant, diet-induced obese rats.

Keywords: endocrinology food appetite hypothalamus Agonism Amylin Leptin obesity