jerry submitted, created time 6 months 1 day (ajp.amjpathol.org)

The hepatocyte growth factor (HGF)/Met signaling system is essential for liver development, homeostasis, and function. In this study, the researchers took advantage of a liver-specific, Met-conditional knockout mouse generated in their laboratory to address the molecular mechanisms of HGF/Met signaling in adult liver progenitor cell (oval cell) biology. It reveals a critical, functional role for Met in oval cell survival through an autocrine mechanism.

Keywords: hepatocyte growth factor apoptosis liver progenitor oval cells liver progenitor cells homeostasis kinases tyrosine methionine HGF