The osteogenicity of implanted engineered bone constructs is related to the density of clonogenic bone marrow stromal cells

BIOBOSS submitted, created time 1 year 7 months (www3.interscience.wiley.com)

Reproducible osteogenicity is a key requirement for the clinical use of bone substitutes based on bone marrow stromal cells (BMSCs) and three-dimensional (3D) scaffolds. In this study we addressed whether a minimal cell density is required for ectopic osteogenicity of constructs generated using a recently developed perfusion system for seeding and culturing human BMSCs on 3D scaffolds.

Keywords: mesenchymal stem cells CFU-f bone tissue engineering bioreactor