p53 Activation: A Case against Sir

jerry submitted, created time 6 months 1 week (www.cancercell.org)

The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress.

In this issue, the researchers screened small-molecule activators of p53 that could potentially reduce tumor growth Tenovin-6 was identified as a potent SIRT1 and SIRT2 inhibitor that indirectly activated p53 at single-digit micromolar concentrations.

The identification of a specific sirtuin inhibitor has broad implications in understanding sirtuin-p53 signaling and the development of novel chemotherapeutics

Keywords: p53-dependent apoptosis tumor growth apoptosis p53