Articles with the keyword:
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Increased Mortality after Dronedarone Therapy for Severe Heart Failure

kavin submitted, created time 1 year 8 months (content.nejm.org)

Background: Dronedarone is a novel antiarrhythmic drug with electrophysiological properties that are similar to those of amiodarone, but it does not contain iodine and thus does not cause iodine-related adverse reactions. Therefore, it may be of value in the treatment of patients with heart failure.

Methods: In a multicenter study with a double-blind design, we planned to randomly assign 1000 patients who were hospitalized with symptomatic heart failure and severe left ventricular systolic dysfunction to receive 400 mg of dronedarone twice a day or placebo

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Treating chronic pain without side-effects?

Sue Wu submitted, created time 2 years 2 months (www.nature.com)

A drug has been found that treats chronic pain in mice, without the usual painkiller side effects of sedation, addiction or developing tolerance.

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Building a New Heart From Old Tissue

Eric wu submitted, created time 2 years 2 months (sciencenow.sciencemag.org)

Approximately 3000 patients in the United States are on the waiting list for a heart transplant, but only about 2000 donor organs become available each year.

This article put forward a new method to solve the life-and-death problem.It includes two pivotal factors:The first one is that we need to find an appropriate stem cell that can give rise to heart tissue;The second one is that the cells require a framework, or scaffolding, to grow on.

Do you think it is feasible to resolve the difficult medical problem?

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Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect

amanda submitted, created time 2 years 10 months (eurheartj.oxfordjournals.org)

"TMZ improves the ED-relaxation in patients with ischaemic cardiomyopathy. The antioxidant properties of TMZ may play a role. "

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Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow

badboy submitted, created time 2 years 11 months (eurheartj.oxfordjournals.org)

" S-SMase is upregulated in CHF, independent of aetiology. The association of S-SMase with clinical status, tissue amount, functional capacity of skeletal muscle tissue, and vasodilator capacity suggests that S-SMase-mediated signalling may contribute to regulatory processes of CHF pathophysiology. "

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