GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

captainclaw submitted, created time 2 years 8 months (www.cell.com)

"In cells undergoing apoptosis, mitochondrial outer-membrane permeabilization (MOMP) is followed by caspase activation promoted by released cytochrome c. Although caspases mediate the apoptotic phenotype, caspase inhibition is generally not sufficient for survival following MOMP; instead cells undergo a “caspase-independent cell death” (CICD). Thus, MOMP may represent a point of commitment to cell death. Here, they identify glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a critical regulator of CICD

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GAPDH is not regulated in human glioblastoma under hypoxic conditions

annatto submitted, created time 2 years 8 months (www.biomedcentral.com)

GAPDH represents an optimal choice of a housekeeping gene and / or loading control to determine the expression of hypoxia induced genes at least in glioblastoma. Because of the lack of GAPDH regulation under hypoxia, this gene is not an attractive target for tumor therapeutic approaches in human glioblastoma.

Submit comment | Blog It | Email It | Keywords: gene expression Human-chimp Gene GAPDH