Interferon-Beta: Mode of Action in EAE

jerry submitted, created time 7 months 1 week (www.immunity.com)

Interferon-β (IFN-β) is widely used in the treatment of multiple sclerosis. However, the underlying molecular mechanism of how it suppresses autoimmunity in the central nervous system is unknown. Researchers find that IFN-β in the brain acts primarily on myeloid cells such as macrophages and microglia to suppress inflammation by blocking several important functions

Submit comment | Blog It | Email It | Keywords: multiple sclerosis EAE IFN-β Interferon-β IFNAR encephalitogenic T cells autoimmunity MS microglia autoimmune disease