DNA damage response confers a barrier for viral tumorigenesis

stephen submitted, created time 1 year 3 months (www.biologynews.net)

Kaposi’s sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi’s sarcoma (KS). KSHV infection is endemic in sub-Saharan Africa where KS is nowadays the most common malignancy, due to widespread infection with KSHV and human immunodeficiency virus (HIV). Importantly, KS also occurs in HIV-negative individuals. Researchers at the University of Helsinki, Finland, have discovered that activation of the DNA damage response in the early stages of KS development functions as an anti-cancer barrier also in virus induced malignancies.

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Finnish Scientists Discover New Approach To Treat Virus-induced Lymphomas

Paramecium submitted, created time 1 year 9 months (www.sciencedaily.com)

Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki have discovered that activation of the p53 pathway offers a novel effective treatment modality for KSHV-infected lymphomas.

Submit comment | Blog It | Email It | Keywords: Virus-induced lymphomas Kaposis sarcoma herpesvirus primary effusion lymphoma