Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association

crackpot submitted, created time 1 year 5 months (www.biomedcentral.com)

"Although ANN analysis was more powerful than the standard haplotype-based test it is unlikely to be taken up widely. The permutation testing necessary to obtain a valid p value makes it slow to perform and it is not underpinned by a theoretical model relating marker genotypes to disease phenotype. Nevertheless, the superior performance of this method does imply that the widely-used haplotype-based methods for detecting association with multiple markers are not optimal and efforts could be made to improve upon them

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Genes bow out of the limelight

DanyC submitted, created time 1 year 6 months (www.abc.net.au)

The most detailed probe yet into the workings of the human genome has led scientists to conclude that a cornerstone concept about the chemical code for life is badly flawed.Analysis of 1% of the human genome has downplayed the role of genes in controlling their own destiny, instead placing so-called junk DNA at centre stage when it comes to gene regulation.The study, published in more than two dozen papers, takes a small percentage of the genome to pieces to draw up a 'parts list', identifying the biological role of every component.

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Macaque Genome Analysis Will Help Find Human Disease Genes

daphne submitted, created time 1 year 8 months (www.medicalnewstoday.com)

Cornell experts in computational biology and bioinformatics have made key contributions to the analysis of the genome of the rhesus macaque, better known as the rhesus monkey. The rhesus macaque (Macaca mulatta) is physiologically similar to humans and therefore widely used in medical research, particularly in vaccine testing and as a model for AIDS research. Understanding its genome and how it differs from that of human beings promises to offer new insights into the evolution of humans and other primates and has important implications for medical research.

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