Articles with the keyword: 
Team finds breast cancer gene linked to metastasis
piggy submitted, created time 2 days 9 hours (www.princeton.edu)
A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in thirty to forty percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.
The gene, called "Metadherin" or MTDH, is located in a small region of human chromosome 8 and appears to be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to blood vessels in distant organs 
Newly identified gene powerful predictor of colon cancer metastasis
piggy submitted, created time 2 weeks 3 days (www.eurekalert.org)
Cancer Researchers at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and the Charité – Universitäts Medizin Berlin (Germany) have identified a gene which enables them to predict for the first time with high probability if colon cancer is going to metastasize. Assistant Professor Dr. Ulrike Stein, Professor Peter M. Schlag, and Professor Walter Birchmeier were able to demonstrate that the gene MACC1 (Metastasis-Associated in Colon Cancer 1) not only promotes tumor growth but also the development of metastasis
Lethal Lint Brush Captures and Kills Cancer Cells in the Bloodstream
piggy submitted, created time 3 weeks 6 days (www.sciencedaily.com)
In a new tactic in the fight against cancer, Cornell researcher Michael King has developed what he calls a lethal "lint brush" for the blood--a tiny, implantable device that captures and kills cancer cells in the bloodstream before they spread through the body.
The strategy, which takes advantage of the body's natural mechanism for fighting infection, could lead to new treatments for a variety of cancers, said King, who is an associate professor of biomedical engineering
jerry submitted, created time 4 months 1 week (sciencenow.sciencemag.org)
A new study in lab mice suggests that cells may break off from a tumor even before they become cancerous, seeding the body with cells that evade detection and lie dormant for years before turning into tumors of their own.
sea-maid submitted, created time 4 months 1 week (www.nature.com)
Non-cancerous mammary cells in mice can take up residence in the lungs and later form tumors. This chance of residence, called metastasis, had previously been thought nearly impossible for ordinary, healthy cells.
Virus helps show how cancer spreads
sea-maid submitted, created time 5 months 3 weeks (news.bbc.co.uk)
Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.
The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.
UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
kavin submitted, created time 5 months 3 weeks (newsroom.ucla.edu)
Using an engineered common cold virus, UCLA researchers delivered a genetic payload to prostate cancer cells that allowed them, using Positron Emission Tomography (PET), to locate the diseased cells as they spread to the lymph nodes, the first place prostate cancer goes before invading other organs.
The tiny cancer metastases in the pelvic lymph nodes are very difficult to find using conventional imaging tools such as CT scanning
New Weapon for Attacking Tumor Invasion and Metastasis
kavin submitted, created time 6 months 2 weeks (www.mphtimes.com)
A team led by Dr. Ji-Kun Li has determined that AMD3100, originally developed in acquired immune deficiency syndrome treatment, could markedly inhibit spreading of colorectal cancer cells by blocking a new pair of ligands and its unique receptor. This effect differs from the usual inhibition by a conventional chemotherapic agent that is more specific to cancer cells with high metastatic potential.
In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration
sea-maid submitted, created time 6 months 3 weeks (www.nature.com)
Some tumours may stimulate the growth of distant cancers within the body. And it is very important for us to know this. We can take some measures to prevent the cancer efficiently. This article discusses some of the forms of early metastasis and tumor promotion by other tumors.
Frequent p16-Independent Inactivation of p14ARF in Human Melanoma
kavin submitted, created time 7 months 3 days (jnci.oxfordjournals.org)
In this paper, the authors observed two or more alterations to the ARF gene in 26/60 (43%) metastases. The p16 gene sustained two or more alterations in 13/60 (22%) metastases (P = .03). Inactivation of ARF in the presence of wild-type p16 was seen in 18/60 (30%) metastases. And the genetic and epigenetic analyses of the human 9p21 locus indicate that modifications of ARF occur independently of p16 inactivation in human melanoma and suggest that ARF is more frequently inactivated than p16.
Mitochondrial Mutations Make Tumors Spread
jane2007 submitted, created time 9 months 4 days (sciencenow.sciencemag.org)
Why is it that cancer often strikes its final, fatal blow when a tumor spreads to other organs? It's because of the metastasis of mitochondrial DNA mutations.
How Do Tumors Spread? Scientists and Engineers Team Up to Solve Mystery
davidd submitted, created time 9 months 3 weeks (www.sciam.com)
Nine out of every 10 cancer deaths occur because the disease has spread. Yet metastasis is the most poorly understood process in cancer biology.
A protein that makes breast cancer spread
jane2007 submitted, created time 9 months 3 weeks (www.nature.com)
A protein that determines whether breast cancer will spread and become deadly has been found. Monitoring for the protein could help patients to know how dangerous their cancer is before it spreads elsewhere and help them to decide which treatment to chose.
Epigenetic Regulation of EpCAM in Tumor Invasion and Metastasis
MedUnion submitted, created time 10 months 3 weeks (www.mupnet.com)
Metastatic progression is the cause of most cancer decease. Many cell surface adhesion molecules are known to be present or re-expressed following gene promoter CpG island hypomethylation in the early stage of growing tumors, but absent or reduced by gene promoter CpG hypermethylation in metastasized carcinomas. Recent studies have revealed that an adhesion receptor, epithelial cell adhesion molecule (EpCAM), mediates cell-cell interaction and is involved in tumor invasion and metastasis. EpCAM expression was associated with promoter CpG methylation in lung adenocarcinoma
Tumor Time Bombs Set Off by Stem Cells
sumsung submitted, created time 11 months 3 weeks (www.sciam.com)
Researchers say they have identified a switch that makes dormant breast cancer cells that have traveled to the lungs swell to lethal proportions—completing the dreaded process of metastasis or cancer spread.
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