Mitochondrial p32 Is a Critical Mediator of ARF-Induced Apoptosis

kavin submitted, created time 5 months 7 hours (www.cancercell.org)

The shared exon 2 of the p14ARF-p16INK4a locus is frequently mutated in human cancers. However, in contrast to the exon 1β-encoded N-terminal half of ARF, the function of the exon 2-encoded C-terminal half of ARF has been elusive. The authors report that the mitochondrial protein p32/C1QBP binds the ARF C terminus. They show that p32 is required for ARF to localize to mitochondria and induce apoptosis, and that ARF mutations specifically disrupting p32 binding can impair both of these functions

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