Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

william submitted, created time 1 year 2 months (www.pnas.org)

Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix–loop–helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle cell (SMC) differentiation.

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Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination

Reviver submitted, created time 1 year 7 months (www.jcb.org)

"Postnatal growth and regeneration of skeletal muscle requires a population of resident myogenic precursors named satellite cells. The transcription factor Pax7 is critical for satellite cell biogenesis and survival and has been also implicated in satellite cell self-renewal; however, the underlying molecular mechanisms remain unclear. Previously, researchers showed that Pax7 overexpression in adult primary myoblasts down-regulates MyoD and prevents myogenin induction, inhibiting myogenesis

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