Derailed endocytosis: an emerging feature of cancer

sea-maid submitted, created time 2 months 1 week (www.nature.com)

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past five years as a multifaceted hallmark of malignant cells

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