p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

Reviver submitted, created time 1 year 6 months (www.jcb.org)

“Clearance of fibrin through proteolytic degradation is a critical step of matrix remodeling that contributes to tissue repair in a variety of pathological conditions, such as stroke, atherosclerosis, and pulmonary disease. However, the molecular mechanisms that regulate fibrin deposition are not known. Here, they report that the p75 neurotrophin receptor (p75NTR), a TNF receptor superfamily member up-regulated after tissue injury, blocks fibrinolysis by down-regulating the serine protease, tissue plasminogen activator (tPA), and up-regulating plasminogen activator inhibitor-1 (PAI-1)

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Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75NTR

daphne submitted, created time 1 year 9 months (www.sciencemag.org)

Differentiation of hepatic stellate cells (HSCs) to extracellular matrix– and growth factor–producing cells supports liver regeneration through promotion of hepatocyte proliferation. We show that the neurotrophin receptor p75NTR, a tumor necrosis factor receptor superfamily member expressed in HSCs after fibrotic and cirrhotic liver injury in humans, is a regulator of liver repair. In mice, depletion of p75NTR exacerbated liver pathology and inhibited hepatocyte proliferation in vivo. p75NTR–/– HSCs failed to differentiate to myofibroblasts and did not support hepatocyte proliferation

Submit comment | Blog It | Email It | Keywords: Cell Differentiation Neurotrophin Receptor Hepatic Stellate Cell