Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways

davis submitted, created time 1 year 2 months (www.pnas.org)

Matrix metalloproteinases (MMPs) are of central importance in the proteolytic remodeling of matrix and the generation of biologically active molecules. MMPs are distinguished by a conserved catalytic domain containing a zinc ion, as well as a prodomain that regulates enzyme activation by modulation of a cysteine residue within that domain.

Submit comment | Blog It | Email It | Keywords: Nitric oxide matrix metalloproteinase-9

Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2

fiona submitted, created time 1 year 7 months (www.cell.com)

"β-adrenergic receptors (β-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target receptors for internalization. Nitric oxide (NO) and/or S-nitrosothiols (SNOs) can prevent the loss of β-AR signaling in vivo, but the molecular details are unknown."

Submit comment | Blog It | Email It | Keywords: β -adrenergic receptors G-protein-coupled receptors Nitric oxide

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310

athena submitted, created time 1 year 8 months (nar.oxfordjournals.org)

"Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1, abbreviated as APE1) is a molecule with dual functions in DNA repair and redox regulation of transcription factors. Accumulated work has shown that the biological activities of APE1 are sensitive to oxidative stress; however, whether APE1 functions can be regulated by nitrosative stress remains unknown."

Submit comment | Blog It | Email It | Keywords: nitric oxide redox regulation transcription factors

Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

athena submitted, created time 1 year 8 months (diabetes.diabetesjournals.org)

"Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation. "

Submit comment | Blog It | Email It | Keywords: nitric oxide vasodilation APPL1

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

cappuccion submitted, created time 1 year 8 months (www.eurekalert.org)

A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time. Nitric oxide is a molecule produced by the body that controls many functions, including the contraction or dilation of blood vessels

Submit comment | Blog It | Email It | Keywords: cardiovascular function pulmonary function Nitric oxide

Nitric oxide mediates prostaglandins' deleterious effect on lipopolysaccharide-triggered murine fetal resorption

addict submitted, created time 1 year 8 months (www.pnas.org)

"Genital tract bacterial infections could induce abortion and are some of the most common complications of pregnancy; however, the mechanisms remain unclear. We investigated the role of prostaglandins (PGs) in the mechanism of bacterial lipopolysaccharide (LPS)-induced pregnancy loss in a mouse model, and we hypothesized that PGs might play a central role in this action. Our results suggest that in a model of septic abortion characterized by increased PG levels, NO might nitrate and thus inhibit COX catalytic activity

Submit comment | Blog It | Email It | Keywords: embryonic resorption uteri decidua peroxynitrite sepsis Nitric oxide

Effects of anti-hypertensive drugs on vessel rarefaction

medal submitted, created time 1 year 8 months (www.sciencedirect.com)

"The microcirculation largely determines peripheral vascular resistance and substantially contributes to arterial hypertension. In both human arterial hypertension and animal models of hypertension, genetic, fetal and other mechanisms associated with hypertension can reduce the formation and number of microvessels (i.e. parallel-connected arterioles and capillaries). Impaired formation of microvessels (impaired angiogenesis) and microvascular rarefaction can, on the other hand, contribute to increased peripheral resistance and raise blood pressure. "

Submit comment | Blog It | Email It | Keywords: microcirculation hypertension blood pressure nitric oxide

Novel aspects of vitamin C: how important is glypican-1 recycling?

amanda submitted, created time 1 year 9 months (www.sciencedirect.com)

"The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins

Submit comment | Blog It | Email It | Keywords: vitamin C ascorbic acid nitric oxide