Epidermal Growth Factor Inhibitors Can Be Used for Molecular Selection of Patients for First-Line Treatment of Advanced Non–Small-Cell Lung Cancer: Not Quite Ready for Prime Time

A 25-Signal Proteomic Signature and Outcome for Patients With Resected Non–Small-Cell Lung Cancer

claudia submitted, created time 1 year 5 months (jnci.oxfordjournals.org)

Among patients with non–small-cell lung cancer (NSCLC), those with poor prognosis cannot be distinguished from those with good prognosis. Matrix-assisted laser desorption–ionization mass spectrometry was used to analyze protein profiles of 174 specimens from NSCLC tumors and 27 specimens from normal lung tissue and to derive a prognosis-associated proteomic signature. Frozen resected tissue specimens were randomly divided into a training set (116 NSCLC and 20 normal lung specimens) and an independent, blinded validation set (58 NSCLC and seven normal lung specimens)

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Randomized Controlled Trial of Resection Versus Radiotherapy After Induction Chemotherapy in Stage IIIA-N2 Non–Small-Cell Lung Cancer

addict submitted, created time 1 year 8 months (jnci.oxfordjournals.org)

Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non–small-cell lung cancer (NSCLC). Maybe following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy. In selected patients with pathologically proven stage IIIA-N2 NSCLC and a response to induction chemotherapy, surgical resection did not improve overall or progression-free survival compared with radiotherapy

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