Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

DanyC submitted, created time 7 months 1 week (www.nature.com)

"Here we show that O-GlcNAc transferase (OGT) harbours a previously unrecognized type of phosphoinositide-binding domain. After induction with insulin, phosphatidylinositol 3,4,5-trisphosphate recruits OGT from the nucleus to the plasma membrane, where the enzyme catalyses dynamic modification of the insulin signalling pathway by O-GlcNAc. This results in the alteration in phosphorylation of key signalling molecules and the attenuation of insulin signal transduction."

Submit comment | Blog It | Email It | Keywords: O-GlcNAc transferase phosphoinositides signal transduction O-GlcNAc insulin IRAP insulin-regulated aminopeptidase insulin receptors OGT