DNA "Tattoos" Link Adult, Daughter Stem Cells in Planarians

sea-maid submitted, created time 3 months 3 weeks (www.sciencedaily.com)

The title of this article is poetic, but it could stand to be better organized. The authors refer to a certain method of DNA identification as a "tattoo," but don't immediately say what it is. One has to dig through the repetitive and error-strewn paragraphs before one finds this:

"the researchers devised methods to detect specific differences in gene expression in the BrdU-labeled cells. The researchers identified 259 genes associated with the stem cells and their daughters

2 comments | Blog It | Email It | Keywords: planarians flatworms stem cells cancer stem cells ovarian stem cells adult stem cells

Asymmetric Self-Renewal and Commitment of Satellite Stem Cells in Muscle

crackpot submitted, created time 1 year 6 months (www.cell.com)

"Satellite cells play a central role in mediating the growth and regeneration of skeletal muscle. However, whether satellite cells are stem cells, committed progenitors, or dedifferentiated myoblasts has remained unclear. Using Myf5-Cre and ROSA26-YFP Cre-reporter alleles, we observed that in vivo 10% of sublaminar Pax7-expressing satellite cells have never expressed Myf5

Submit comment | Blog It | Email It | Keywords: human mesenchymal stem cells Ovarian Stem Cells

alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis

DanyC submitted, created time 1 year 6 months (www.carcinogenesis.com)

"Researchers demonstrate that ovarian cancer cell lines grown as spheroids can sustain growth for 10 days while the normal ovarian cell line failed to grow beyond 2 days. Compared to cells grown as a monolayer, cancer cells grown as spheroids demonstrated no change in adhesion for up to 4 days, while IOSE29 cells had a 2-4-fold loss of adhesion within 2 days. Cancer cell spheroids disaggregated on extracellular matrices (ECM) and demonstrated enhanced expression of secreted pro-MMP2 as well as activated MMP2/MMP9 with no such activation of MMP's observed in monolayer cells

Submit comment | Blog It | Email It | Keywords: primary visual cortex breast cancer cells Ovarian Stem Cells Natural killer (NK) cells

Gonadotropins and Ovarian Cancer

DanyC submitted, created time 1 year 7 months (edrv.endojournals.org)

"Ovarian carcinomas have been found to express specific receptors for gonadotropins. The presence of gonadotropins in ovarian tumor fluid suggests the importance of these factors in the transformation and progression of ovarian cancers as well as being prognostic indicators. Functionally, there is evidence showing a direct action of gonadotropins on ovarian tumor cell growth. This review summarizes the key findings and recent advances in our understanding of these peptide hormones in ovarian cancer development and progression and their role in potential future cancer therapy

Submit comment | Blog It | Email It | Keywords: ovarian cancers Ovarian Stem Cells gonadotropins

Ginger, a potential cure for ovarian cancer

Reviver submitted, created time 1 year 9 months (health.allrefer.com)

"Try eating ginger in your daily diet if you are suffering fropm ovarian cancer, for researchers at the University of Michigan Comprehensive Cancer Center have found that it causes ovarian cancer cells to die."

Submit comment | Blog It | Email It | Keywords: Cancer Treatment Ovarian Stem Cells

Dcr-1 Maintains Drosophila Ovarian Stem Cells

claudia submitted, created time 1 year 9 months (www.current-biology.com)

"MicroRNAs (miRNAs) regulate gene expression by controlling the turnover, translation, or both of specific mRNAs. In Drosophila, Dicer-1 (Dcr-1) is essential for generating mature miRNAs from their corresponding precursors. Because miRNAs are known to modulate developmental events, such as cell fate determination and maintenance in many species, we investigated whether a lack of Dcr-1 would affect the maintenance of stem cells (germline stem cells, GSCs; somatic stem cells, SSCs) in the Drosophila ovary by specifically removing its function from the stem cells

Submit comment | Blog It | Email It | Keywords: Dcr-1 Ovarian Stem Cells