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MYPT1 regulates mitosis by antagonizing Plk1

jerry submitted, created time 7 months 2 weeks (www.developmentalcell.com)

This study identifies a previously unrecognized role of MYPT1 in regulating mitosis by antagonizing PLK1. MYPT1 binds to PP1C. This binding is believed to target PP1C to specific substrates including myosin II, thus controlling cellular contractility.

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