Gene shots ease symptoms of Parkinson's disease

DanyC submitted, created time 1 year 6 months (www.newscientist.com)

At last gene therapy may be living up to its promise. Dramatic and sustained improvements have been reported in the first people to get gene therapy for Parkinson's disease.

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Study: Gene therapy success for Parkinson's patients

DanyC submitted, created time 1 year 6 months (www.newscientist.com)

Researchers say,the first attempt to treat Parkinson's disease with gene therapy reduced symptoms by as much as 70%.

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Gene therapy treatment offers Parkinson's relief

Reviver submitted, created time 1 year 6 months (www.reutershealth.com)

Two studies published on Thursday offer new hope for Parkinson's disease -- one using gene therapy to treat the symptoms and another investigating a drug that might stop the incurable disease in its tracks.

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PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

diggman submitted, created time 1 year 6 months (biology.plosjournals.org)

"Mutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been reported, and the mechanism by which PINK1 mutations lead to neurodegeneration is unknown. Here we report the identification of TNF receptor-associated protein 1 (TRAP1), a mitochondrial molecular chaperone also known as heat shock protein 75 (Hsp75), as a cellular substrate for PINK1 kinase. PINK1 binds and colocalizes with TRAP1 in the mitochondria and phosphorylates TRAP1 both in vitro and in vivo."

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