Old gastrointestinal drug slows neurodegenerative diseases

sea-maid submitted, created time 15 hours 30 minutes (www.eurekalert.org)

Recent animal studies have shown that clioquinol – an eighty-year-old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders.

Researchers at McGill University have discovered a dramatic possible new answer: According to Dr

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Computational Systems Analysis of Dopamine Metabolism

jerry submitted, created time 6 months 4 days (www.plosone.org)

A prominent feature of Parkinson's disease (PD) is the loss of dopamine in the striatum, and many therapeutic interventions for the disease are aimed at restoring dopamine signaling. Dopamine signaling includes the synthesis, storage, release, and recycling of dopamine in the presynaptic terminal and activation of pre- and post-synaptic receptors and various downstream signaling cascades

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Metabolic correlates of subthalamic nucleus activity in Parkinson's disease

kavin submitted, created time 7 months 4 weeks (www.ncbi.nlm.nih.gov)

In this paper, the authors scanned 17 PD patients with (18)F-fluorodeoxyglucose (FDG) PET to measure resting glucose metabolism before the implantation of STN deep brain stimulation electrodes. The findings suggest that the functional pathways associated with motor disability in PD are linked to the STN firing rate. These pathways are likely to mediate the clinical benefit that is seen following targeted STN interventions for this disease.

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Handwriting can give us a sign about our heart?

DanyC submitted, created time 1 year 1 month (www.abc.net.au)

Here we could get some interesting information from" Handwriting production might be affected by some disorders (eg Parkinson's disease) but this is not to say that handwriting style can be an indicator of disease, and specifically heart disease",
As far as I know there isn't any evidence to correlate heart disease with handwriting style, or to suggest that handwriting style can be used to accurately diagnose illness, but I think this may be a key way to predict heart disease without the need for invasive and expensive techniques, maybe it will be true in the future.

2 comments | Blog It | Email It | Keywords: Pharmacology heart disease graphonomy Parkinson's disease