Articles with the keyword: 
Older antidepressants work for Parkinson patients
piggy submitted, created time 2 weeks 5 days (www.reuters.com)
People with Parkinson's disease who also suffer from depression may find they're helped more by an older class of antidepressants than newer types of medication, a small clinical trial sponsored by the National Institutes of Health suggests.
The study found that paroxetine (brand name, Paxil), a so-called SSRI antidepressant, appears to be less effective than the "tricyclic" antidepressant nortriptyline for treating depression in patients with Parkinson's disease.
"Depression in Parkinson's disease is underrecognized, underappreciated and undertreated," lead investigator Dr 
james submitted, created time 1 year 2 months (www.pnas.org)
Bilateral, high-frequency stimulation (HFS) of the subthalamic nucleus (STN) is the surgical therapy of choice for movement disability in advanced Parkinson's disease (PD), but this procedure evokes debilitating psychiatric effects, including depressed mood, of unknown neural origin.
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
davis submitted, created time 1 year 4 months (www.pnas.org)
Parkinson's disease (PD) is a common neurodegenerative movement disorder. Whereas the majority of PD cases are sporadic, rare genetic defects have been linked to this prevalent movement disorder.
InfoMax gene networks constructed from intervention in the animal models of Parkinson's disease
Scarlett submitted, created time 1 year 5 months (www.biomedcentral.com)
InfoMax Gene Network, a new network structure for exploring genome-scale inter-relationships among families of genes in order to specify pathways activated during the experiments that perturb a control system. Application of information theory to the above-mentioned signals provides a collection of gene families in the genomic space that indicate the nodes of the InfoMax Gene Network.
Study finds smoking wards off Parkinson's disease
DanyC submitted, created time 1 year 5 months (www.reutershealth.com)
Researchers reported on Monday, there is more evidence to back up a long-standing theory that smokers are less likely to develop Parkinson's disease than people who do not use tobacco products.
Tracing Parkinson's lethal mechanism
bianjie submitted, created time 1 year 6 months (www.eurekalert.org)
In the vast majority of Parkinson's disease patients, the disorder arises not because of a genetic defect, but because some external insult triggers the death of dopamine-producing neurons. Now, researchers have reported progress in understanding the mechanism underlying that death, which they say suggests a new treatment pathway.
annatto submitted, created time 1 year 6 months (www.jneurosci.org)
"The molecular basis of L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID), one of the major hindrances in the current therapy for Parkinson's disease, is still unclear. We show that attenuation of cAMP signaling in the medium spiny neurons of the striatum, achieved by genetic inactivation of the dopamine and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), reduces LID. We also show that, in dyskinetic mice, sensitized cAMP/cAMP-dependent protein kinase/DARPP-32 signaling leads to phosphorylation/activation of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2)
Early environmental exposure may accelerate age-related neurodegeneration
BIOBOSS submitted, created time 1 year 6 months (www.eurekalert.org)
Exposure to iron during the first weeks of life in combination with exposure later in life to a common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinson's disease (PD), according to a new study in mice. The findings also showed that a compound that protects cells in the body from damage from certain forms of oxygen, a kind of antioxidant, could suppress such neural degeneration.
addict submitted, created time 1 year 6 months (www.pnas.org)
Stem cells have been widely assumed to be capable of replacing lost or damaged cells in a number of diseases, including Parkinson's disease (PD), in which neurons of the substantia nigra (SN) die and fail to provide the neurotransmitter, dopamine (DA), to the striatum
Parkinson's Gene Therapy Breakthrough May Enter Clinical Trials by Year-End
seanangel submitted, created time 1 year 6 months (www.sciam.com)
Promising results delivered in the first human clinical trial testing the procedure against the neurodegenerative disorder
Stem cells help primates with Parkinson's
sciencebaby submitted, created time 1 year 6 months (www.nature.com)
Human stem cell transplants have eased the symptoms of Parkinson's disease in a monkey model of the brain disorder. The study, which brings the prospect of human trials one step closer, hints that stem cells do more than just replace cells — they may help persuade the brain to heal itself.
Drug slows and may halt Parkinson's disease
bioman submitted, created time 1 year 6 months (www.eurekalert.org)
Northwestern University researchers have discovered a drug that slows and may even halt the progression of Parkinson's disease. The drug rejuvenates aging dopamine cells, whose death in the brain causes the symptoms of this devastating and widespread disease.
DanyC submitted, created time 1 year 7 months (www.jneurosci.org)
"Here, Researchers report that in animals subjected to an intrastriatal 6-hydroxydopamine lesion of the striatal dopaminergic afferent, the integrity of the host dopaminergic innervation outside the areas innervated by the graft is critical for optimal function of DA neurons placed in the striatum. Established graft-induced functional recovery, as assessed in the stepping and cylinder tests, was compromised in animals in which the dopaminergic lesion was extended to include also the medial and ventral striatum as well as the cortical and limbic DA projections
Improvement In Animal Model Of Parkinson's Obtained By Implanting Dopamine Generators In Brain Cells
Luneetty submitted, created time 1 year 7 months (www.medicalnewstoday.com)
Implanting dopamine generators (dopaminergics) in brain cells has produced improvement in the symptoms in Parkinson's, according to the results of tests carried out with monkeys by the Navarra University Hospital, led by Dr María Rosario Luquin Piudo, neurologist at the Hospital and at the other Navarra University-based medical centre, CIMA (the Research Centre for Applied Medicine).
newsdigg submitted, created time 1 year 7 months (www.pnas.org)
The orphan G protein-coupled receptor 37 (GPR37) is a substrate of parkin; its insoluble aggregates accumulate in brain samples of Parkinson's disease patients. We report here that GPR37 interacts with the dopamine transporter (DAT) and modulates DAT activity. GPR37 and DAT were found colocalized in mouse striatal presynaptic membranes and in transfected cells and their interaction was confirmed by coimmunoprecipitation assays.
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