How cells save their energy

A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality

annatto submitted, created time 1 year 6 months (www.biomedcentral.com)

"Researchers demonstrate that our scoring method can generate an integrated high-confidence subset of observed matrix-model interactions, which they subsequently used to derive an accurate map of yeast complexes. Their results indicate that essentiality is a product of the protein complex rather than the individual protein, and that they have achieved near saturation of the yeast high-abundance, rich-media-expressed 'complex-ome'."

Submit comment | Blog It | Email It | Keywords: gene protein complex protein-DNA complexes

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

DanyC submitted, created time 1 year 6 months (www.jcb.org)

"Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1{alpha} (HIF-1{alpha}) protein. How cells transduce hypoxic signals to stabilize the HIF-1{alpha} protein remains unresolved. Researchers demonstrate that cells deficient in the complex III subunit cytochrome b, which are respiratory incompetent, increase ROS levels and stabilize the HIF-1{alpha} protein during hypoxia

Submit comment | Blog It | Email It | Keywords: p38 alpha mitogen-activated protein Protein Complex