Articles with the keyword: 
Scientists Pull Protein's Tail to Curtail Cancer
piggy submitted, created time 5 days 10 hours (www.sciencedaily.com)
When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells’ membranes and foiling cancer growth.
This phenomenon of delinquency puzzled scientists for a long time — until a cell biologist in the Johns Hopkins University School of Medicine felt compelled to genetically grab the protein by the tail and then watched as it got back to work at tamping down disease 
Fat cells also linked to prion infection
sea-maid submitted, created time 1 week 23 hours (www.sciencenews.org)
Researchers have confirmed that adipose cells can carry prions, or at least that healthy test animals injected with infected fat cells become sick.
Prions are small, non-living chunks of misfolded proteins that can cause diseases such as scrapie and mad cow disease.
piggy submitted, created time 2 weeks 1 hour (sciencenow.sciencemag.org)
Talk about Dr. Jekyll and Mr. Hyde. Misfolded proteins known as prions cause mad cow disease and other fatal neurodegenerative illnesses. But in their properly folded form, the proteins may be important to survival, helping mice and other animals keep their sniffing skills sharp, new research shows.
Prions get the bad reputation--and the lion's share of research attention--but interest in the normal form of prion proteins is increasing
New technique is quantum leap forward in understanding proteins
piggy submitted, created time 2 weeks 1 day (www.eurekalert.org)
In this ongoing quest, a group of Scripps Research Institute scientists, along with colleagues from the University of California, San Diego, (UCSD) have borrowed from physics to deliver one of those research rarities—an unmitigated success. The group has devised a computational method that, with remarkable accuracy, predicts how bacterial proteins fold and interact
Fatal protein interactions may explain neurological diseases
sea-maid submitted, created time 4 months 4 days (esciencenews.com)
In a collaborative study at the University of California, San Diego, investigators from neurosciences, chemistry and medicine, as well as the San Diego Supercomputer Center (SDSC) have investigated how proteins involved in neurodegenerative diseases such as Alzheimer's and Parkinson's disease interact to form unique complexes. Their findings explain why Alzheimer's patients might develop Parkinson's, and vice versa. The new and unique molecular structures they discovered can now be used to model and develop new drugs for these devastating neurological diseases
Scientists develop new method to investigate origin of life
sea-maid submitted, created time 4 months 5 days (esciencenews.com)
Scientists at Penn State have developed a new computational method that they say will help them to understand how life began on Earth. The team's method has the potential to trace the evolutionary histories of proteins all the way back to either cells or viruses, thus settling the debate once and for all over which of these life forms came first. "We have just begun to tap the potential power of this method," said Randen Patterson, a Penn State assistant professor of biology and one of the project's leaders
Researchers unveil vital key to cancer
sea-maid submitted, created time 5 months 1 day (www.manchester.ac.uk)
University of Manchester scientists have uncovered the 3D structure of Mps1 – a protein that regulates the number of chromosomes during cell division and thus has an essential role in the prevention of cancer – which will lead to the design of safer and more effective therapies.
A Lipidic-Sponge Phase Screen for Membrane Protein Crystallization
jerry submitted, created time 5 months 3 weeks (www.structure.org)
A major current deficit in structural biology is the lack of high-resolution structures of eukaryotic membrane proteins, many of which are key drug targets for the treatment of disease. Numerous eukaryotic membrane proteins require specific lipids for their stability and activity, and efforts to crystallize and solve the structures of membrane proteins that do not address the issue of lipids frequently end in failure rather than success. To help address this problem, they have developed a sparse matrix crystallization screen consisting of 48 lipidic-sponge phase conditions
First direct observations of protein-synthesis mechanism
jane2007 submitted, created time 9 months 3 days (www.ucsc.edu)
An UCSC scientist and his collaborators have made the first direct observations of the mechanism for protein synthesis in living cells.
Serum Levels of Apolipoprotein A-II as a Potential Marker for Cholangiocarcinoma
MedUnion submitted, created time 10 months 3 weeks (www.mupnet.com)
AIM: Cholangiocarcinoma (CC) is a devastating neoplasm usually hard to get diagnosed in the early stage due to the unfavorable anatomic location. The currently used tumor markers like CEA and CA 19-9 are not always helpful because of the unsatisfactory sensitivities and specificities. In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) was used to identify the potential biomarker for CC
Transcriptomic and Proteomic Analyses of Pericycle Cells of the Maize Primary Root
yangjane submitted, created time 1 year 1 month (www.plantphysiol.org)
Each plant cell type expresses a unique transcriptome and proteome at different stages of differentiation dependent on its developmental fate. This study compared gene expression and protein accumulation in cell-cycle-competent primary root pericycle cells of maize (Zea mays) prior to their first division and lateral root initiation. These are the only root cells that maintain the competence to divide after they leave the meristematic zone.
MIT scholars discover key blood protein
Hecate submitted, created time 1 year 2 months (www.eurekalert.org)
Ah, some blood-based news just weeks before Halloween. It seems that a team led by Dr. Jane-Jane Chen of MIT has uncovered a protein, nicknamed HRI for short, that regulates the body's iron recycling system. This may have consequences for people suffering from protoporphyria.
(You will have to click into the article for the full name. This is good news, but I don't want to give myself carpal tunnel syndrome for it.)
GenScript Named VWR Biosciences CRO Partner
BIOBOSS submitted, created time 1 year 7 months (www.genscript.com)
International research outsourcing company GenScript Corporation has been added to VWR Biosciences' prestigious list of molecular biology partners in both proteomics and genomics.
Iterative proteomics on the fly
yoyotaxi submitted, created time 1 year 7 months (www.nature.com)
Understanding how proteins and their complex interaction networks convert the genomic information into a dynamic living organism is a fundamental challenge in biological sciences. As an important step towards understanding the systems biology of a complex eukaryote, researchers cataloged 63% of the predicted Drosophila melanogaster proteome by detecting 9,124 proteins from 498,000 redundant and 72,281 distinct peptide identifications
MedUnion submitted, created time 1 year 8 months (www.mupnet.com)
AIM: To decipher the key biochemical modulators of tumorigenesis and evaluate the potential of candidate proteins as biomarkers or targets for novel therapeutic intervention of colorectal cancer (CRC).
METHODS: Differentially expressed proteins in colorectal tumors were identified by gel-based proteomics, tandem mass spectrometry and NCBInr database interrogation, and further validated by Western blotting and immunohistochemical (IHC) staining
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