Dynamics of RASSF1A/MOAP-1 Association with Death Receptors

kavin submitted, created time 6 months 3 days (www.ncbi.nlm.nih.gov)

RASSF1A associated with the TNF-R1/MOAP-1 or TRAIL-R1/MOAP-1 complex via its N-terminal cysteine-rich (C1) domain containing a potential zinc finger binding motif. Importantly, TNF-R1 association domains on both MOAP-1 and RASSF1A were essential for death receptor-dependent apoptosis. The association of RASSF1A and MOAP-1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation.

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RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesis

Reviver submitted, created time 1 year 4 months (www.molecular-cancer.com)

"This methylation and expression data support the hypothesis that RASSF1A is involved in early tumorigenesis of renal cell carcinoma."

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