CD4(+) T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25(+) T cells

Immunology submitted, created time 1 year 1 month (www.ncbi.nlm.nih.gov)

BACKGROUND: The human 5T4 (h5T4) oncofoetal antigen is expressed by a wide variety of human carcinomas including colorectal, ovarian, gastric and renal, but rarely on normal tissues. Its restricted expression on tumour tissues as well as its association with tumour progression and bad prognosis has driven the development of a MVA-based vaccine (TroVax) which has been tested in several early phase clinical trials and these studies have led to the start of a phase III trial in renal cell carcinoma patients

Submit comment | Blog It | Email It | Keywords: kidneys RCC T-cells immunology cancer 5T4 T regulatory cells human renal cell carcinoma human renal cell carcinoma (RCC) CD4+ T cells

Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins

DanyC submitted, created time 1 year 6 months (www.translational-medicine.com)

“Sunitinib treatment in advanced RCC patients leads to modulation of plasma levels of circulating proteins involved in VEGF signaling, including soluble forms of two VEGF receptors. This panel of proteins may be of value as biomarkers of the pharmacological and clinical activity of sunitinib in RCC, and of angiogenic processes in cancer and other diseases.”

Submit comment | Blog It | Email It | Keywords: VEGF circulating proteins RCC