Articles with the keyword: 
sea-maid submitted, created time 1 month 3 weeks (www.jcb.org)
Active genes can be sociable, snuggling up to one another. Brown et al. offer a new explanation for this clustering, suggesting that genes gather for the services of RNA splicing enzymes
A gene's location in the nucleus often reflects its activity. Hard-working genes tend to congregate in the interior of the nucleus, whereas their lazier counterparts hang out at the edge. Moreover, active genes on different chromosomes sometimes bunch up. How often active genes come together is uncertain 
Experimental RNA drug may cause blindness
lavrock submitted, created time 2 months 3 weeks (www.nature.com)
Caution needed in clinical trials, scientists urge.
Life Cooked Up in Outer Space?
jerry submitted, created time 5 months 4 days (sciencenow.sciencemag.org)
The odds are improving that life exists beyond Earth. A European-U.S. team reports that a meteorite that formed billions of years ago and eventually crashed on our planet harbors two important components of RNA and DNA, the fundamental molecules of life. The findings could help explain how life got started on Earth, and they suggest that the ingredients for life have been liberally sprinkled throughout the solar system, if not the galaxy.
sea-maid submitted, created time 6 months 1 week (www.cell.com)
With regards to the survival of motor neurons (SMN), certain proteins are essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA splicing machinery.
This article suggests that SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing.
Applied Force Reveals Mechanistic and Energetic Details of Transcription Termination
davidd submitted, created time 7 months 2 weeks (www.cell.com)
Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. They used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). And they propose a quantitative, energetic model that predicts the behavior for these terminators and mutant variants.
davidd submitted, created time 7 months 3 weeks (www.pnas.org)
Small RNAs (21–24 nt) are involved in gene regulation through translation inhibition, mRNA cleavage, or directing chromatin modifications. At least five classes of these small regulatory RNAs (21–24 nt) have been characterized. miRNA and siRNA is reported frquently. However, the natural antisense miRNAs (nat-miRNAs) have not been reported in any system.
"Junk" RNA may play a role in vertebrate evolution
sumsung submitted, created time 9 months 1 week (www.sciam.com)
Genetic material once dismissed as mere "junk" may in fact be responsible to the evolution of simple invertebrates into more complex organisms sporting backbones, according to a new study.
Sifting the Genome for Clues to Cancer
sumsung submitted, created time 9 months 3 weeks (sciencenow.sciencemag.org)
Biologists have hunted for weak spots in cancer cells for years, hoping to find clues to the disease that can be exploited. That should get easier thanks to a mass-screening technique reported in the 1 February issue of Science that may provide a cost-effective and powerful way to pick out new drug targets against cancer.
wugongliang submitted, created time 1 year 2 weeks (sciencenow.sciencemag.org)
Researchers have hit upon a new way to stop the pesky critters that destroy crops: They've genetically engineered plants to express insect-killing RNA molecules. The new approach could pave the way for more targeted--and environmentally friendly--pest control.
DanyC submitted, created time 1 year 4 weeks (www.jcb.org)
"The retained mRNAs maintain the ability to recruit components of the exon junction complex and the nuclear exosome subunit Rrp6p, suggesting that binding of these proteins is not sufficient for RNA release. Researchers propose that the missing heptads in the truncated CTD mutant are required for binding of proteins implicated in a final co-transcriptional maturation of spliced and 3' end cleaved and polyadenylated mRNAs into export-competent ribonucleoprotein particles."
Novel zinc-based fixative for high quality DNA, RNA and protein analysis
Luneetty submitted, created time 1 year 5 months (nar.oxfordjournals.org)
"We have developed a reliable, cost-effective and non-toxic fixative to meet the needs of contemporary molecular pathobiology research, particularly in respect of RNA and DNA integrity. The effects of 25 different fixative recipes on the fixed quality of tissues from C57BL/6 mice were investigated. This improved, non-toxic and economical tissue fixative could be applied for routine use in pathology laboratories to permit subsequent genomic/proteomic studies."
Scientists decode RNA mystery, will help aim drug therapies
deirdre submitted, created time 1 year 5 months (www.eurekalert.org)
As reported in the June 13 issue of the online journal PLoS ONE, the researchers, led by Jonathan Dinman, assistant professor of cell biology and molecular genetics at the University of Maryland, have found the difference between two closely related components in the messenger RNA (mRNA) � near-cognate and non-cognate codons' terms that have long been used, but not understood.
The THI-box Riboswitch, or How RNA Binds Thiamin Pyrophosphate
Cindy submitted, created time 1 year 7 months (www.sciencedirect.com)
Riboswitches are genetic control elements present mainly in the 5′ untranslated regions of messenger RNAs that, upon binding of a small metabolite (like some vitamins, amino acids, and nucleobases), undergo conformational changes, affecting the expression of downstream genes. Structural studies of riboswitches are important for understanding how they recognize their ligands with high specificity and affinity. The thiamin pyrophosphate binding riboswitch (THI- box) is widely distributed in the three kingdoms of life and is involved in very distinct modes of gene regulation
For tumors without p53, a way to improve chemotherapy at lower doses
Darkfrog submitted, created time 1 year 9 months (web.mit.edu)
A new study out of MIT establishes that many tumors lacking the p53 gene -- about 80% of all human tumors, then -- use the MK2 signalling inflammatory pathway to protect themselves from the effects of chemotherapy. Using RNA interference, the researchers knocked out the inflammatory pathways. Even exposed to small amounts of chemotherapeutic agents, the tumors "melted away."
Cryo-Electron Microscopy of Spliceosomal Components
BIOBOSS submitted, created time 1 year 9 months (users.sdsc.edu)
[Full Text]The spliceosome is formed by the stepwise integration of five snRNPs composed of U1, U2, U4, U5, and U6 snRNAs and more than 150 proteins binding sequentially to pre-mRNA. To study the structure of this particularly dynamic RNP machine that undergoes many changes in composition and conformation, single-particle cryo-electron microscopy (cryo-EM) is currently the method of choice
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