Articles with the keyword: 
New Pathway for Malaria Infection Discovered
sea-maid submitted, created time 2 months 1 week (www.sciencedaily.com)
Cenix BioScience GmbH, a leading specialist in advanced RNA interference (RNAi)-based research services, Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and the Lisbon-based biomedical research centre Instituto de Medicina Molecular (IMM), have announced the publication of their collaborative study in Cell Host & Microbe, describing the discovery and in vivo validation of scavenger receptor BI (SR-BI), a major regulator of cholesterol uptake by the liver, as a critical host factor for malaria infection. 
Coupling of Double-Stranded RNA Synthesis and siRNA Generation
jerry submitted, created time 5 months 2 weeks (www.sciencedirect.com)
A new study shows that heterochromatic dsRNA synthesis and siRNA generation are physically coupled processes. This coupling has implications for cis-restriction of siRNA-mediated heterochromatin assembly and for mechanisms that give rise to siRNA strand polarity.
An endogenous small interfering RNA pathway in Drosophila
kavin submitted, created time 6 months 1 week (www.nature.com)
Endogenous small RNAs of Drosophila join Argonaute-1 to regulate gene expression. Here the authors show that Drosophila generates a third small RNA class, endogenous small interfering RNAs, in both gonadal and somatic tissues.
RNA interferrence and transcription of DNA silencing
sea-maid submitted, created time 7 months 2 hours (www.jcb.org)
In order to resolve the paradox existing in the inheritence -RAN interference and transcription,the experiment used the yeast centromeres was carried out. From this article, we can find some reasons for the aboving paradox.
From sequence to function: using RNAi to elucidate mechanisms of human disease
davidd submitted, created time 7 months 1 week (www.nature.com)
RNA interference (RNAi) has emerged as one of the most powerful tools for functionally characterizing large sets of genomic data. The capabilities of RNAi place it at the forefront of high-throughput screens, which are able to span the human genome in search of novel targets. The article assess the prospective applications of high-throughput screens, the data they are capable of generating, and the potential for this technique to further our understanding of human disease.
Triumphs and tribulations for RNA interference
jane2007 submitted, created time 7 months 3 weeks (www.nature.com)
Two studies highlight promise and problems for gene silencing technique. Researchers could offer a new way by microRNA interference to treat conditions from cancer to cardiovascular disease. But another study shows that the effects of RNAi on genes involved in a severe form of blindness called age-related macular degeneration (AMD). In this case RNAi-causing drugs have already gone into trials. It isn't that the drugs don't work; it's that they work no matter what siRNA sequence is used. This brings the current understanding of the mechanism of RNA interference into question.
Eric wu submitted, created time 11 months 1 week (sciencenow.sciencemag.org)
The female fruit fly is a faithful lover, at least for a little while. As soon as she mates, she rejects all suitors for several days and spends her time laying eggs. Biologists have now found the switch that controls this coy female behavior, to the pleasure of male flies and disease researchers alike.
bianjie submitted, created time 1 year 1 month (www.pnas.org)
RNA interference requires efficient delivery of small double-stranded RNA molecules into the target cells and their subsequent incorporation into RNA-induced silencing complexes. Although current cationic lipids commonly used for DNA transfection have also been used for siRNA transfection, a clear need still exists for better siRNA delivery to improve the gene silencing efficiency.
Silencing of genes in cultured Drosophila neurons by RNA interference
bianjie submitted, created time 1 year 3 months (www.pnas.org)
Cultures of neuroblasts that generate abundant neurons were established from Drosophila embryos to study silencing of genes by RNA interference (RNAi). Cultured cells expressed ELAV, a marker of neurons, Futsch, a marker of neurites, and Synapsin, Synaptobrevin, and Synaptogamin, proteins involved in neurotransmitter secretion.
DNA Computer Works in Human Cells
julie submitted, created time 1 year 6 months (www.sciam.com)
"Researchers have designed a new type of DNA computer that works in human cells, perhaps paving the way for a distant technology capable of picking out diseased cells from otherwise healthy tissue. The system runs on a process called RNA interference (RNAi) in which small molecules of RNA prevent a gene from producing protein. "
High-throughput screening by RNA interference: control of two distinct types of variance
easternblot submitted, created time 1 year 6 months (www.landesbioscience.com)
Guidelines for RNA interference screen development.
The code that could unlock cancer
alpha submitted, created time 1 year 7 months (edition.cnn.com)
"Scientists have unlocked the genetic code that could pave the way to a new generation of highly effective cancer drugs with none of the painful side effects of existing treatments."
For tumors without p53, a way to improve chemotherapy at lower doses
Darkfrog submitted, created time 1 year 9 months (web.mit.edu)
A new study out of MIT establishes that many tumors lacking the p53 gene -- about 80% of all human tumors, then -- use the MK2 signalling inflammatory pathway to protect themselves from the effects of chemotherapy. Using RNA interference, the researchers knocked out the inflammatory pathways. Even exposed to small amounts of chemotherapeutic agents, the tumors "melted away."
Getting on your nerves... and repairing them
penguin submitted, created time 1 year 9 months (www.eurekalert.org)
A key molecular mechanism, RNA interference (RNAi), plays a role in the regeneration and repair of periphery nerves, which are the nerves located outside of the brain and spinal column. This research may lead to new therapies that manipulate RNAi to treat people with damaged nerves resulting from degenerative disorders and injury.
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