Life without RNase P.

kavin submitted, created time 8 months 1 day (www.ncbi.nlm.nih.gov)

The universality of ribonuclease P (RNase P), the ribonucleoprotein essential for transfer RNA (tRNA) 5' maturation, is challenged in the archaeon Nanoarchaeum equitans. In this study, the researchers's findings demonstrate how nature can cope with the loss of the universal and supposedly ancient RNase P through genomic rearrangement at tRNA genes under the pressure of genome condensation.

3 comments | Blog It | Email It | Keywords: transfer RNA tRNA splicing Nanoarchaeum equitans tRNA tRNA stability RNase P RNA

RNA splicing factor implicated in ovarian tumor cell growth

amanda submitted, created time 1 year 8 months (www.biologynews.net)

"An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago."

Submit comment | Blog It | Email It | Keywords: ovarian cancer ovarian neoplasms RNase P RNA RNA polymerase III

Deciphering RNA structural diversity and systematic phylogeny from microbial metagenomes

cappuccion submitted, created time 1 year 9 months (nar.oxfordjournals.org)

Metagenomics has been employed to systematically sequence, classify, analyze and manipulate the entire genetic material isolated from environmental samples. Finding genes within metagenomic sequences remains a formidable challenge, and noncoding RNA genes other than those encoding rRNA and tRNA are not well annotated in metagenomic projects. In this work, scientists identify, validate and analyze the genes coding for RNase P RNA (P RNA) from all published metagenomic projects

Submit comment | Blog It | Email It | Keywords: microbial metagenomes RNase P RNA systematic phylogen RNA structural diversity