Abl tyrosine kinases regulate cell–cell adhesion through Rho GTPases

bachelor submitted, created time 1 year 1 month (www.pnas.org)

Adherens junctions are calcium-dependent cell–cell contacts that link neighboring cells through cadherin receptors. Coordinated regulation of the actin cytoskeleton by the Rho GTPases is required for the formation and dissolution of adherens junctions. However, the pathways that link cadherin signaling to cytoskeletal regulation remain poorly defined. Here we identify the Abl family kinases as critical mediators of cadherin-mediated adhesion

Submit comment | Blog It | Email It | Keywords: Crk calcium cytoskeleton Rac cadherin adherens junctions

Rac, membrane heterogeneity, caveolin and regulation of growth by integrins

amanda submitted, created time 1 year 7 months (www.sciencedirect.com)

"Anchorage dependence of growth blocks cell proliferation in inappropriate environments, thereby inhibiting cancer cell invasion and metastasis. Inhibition of growth regulatory pathways, including Rac, Erk and PtdIns 3-kinase in non-adherent cells mediates this effect. Here, we review recent work showing that integrin-mediated adhesion controls Rac binding to membranes. Rac binding sites can be found within cholesterol-enriched membrane domains, which are internalized when cells are deprived of adhesion

Submit comment | Blog It | Email It | Keywords: cell proliferation cancer cell membrane heterogeneity Rac integrins