Surviving the Breakup: The DNA Damage Checkpoint

BIOBOSS submitted, created time 1 year 10 months (openwetware.org)

[Full Text]In response to even a single chromosomal double-strand DNA break, cells enact the DNA damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to repair damaged chromosomes before entering mitosis. This mechanism helps prevent the segregation of damaged or mutated chromosomes and thus promotes genomic stability

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