Articles with the keyword:
9

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

jerry submitted, created time 5 months 5 days (www.genesdev.org)

Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.

6

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis

jimmy submitted, created time 1 year 1 month (www.pnas.org)

Deregulation of the Myc pathway and deregulation of the Rb pathway are two of the most common abnormalities in human malignancies. Recent in vitro experiments suggest a complex cross-regulatory relationship between Myc and Rb that is mediated through the control of E2F.

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