Monkeys add up like we do

HIF-prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and fetal hemoglobin expression in rhesus macaques

dovechocolate submitted, created time 1 year 6 months (bloodjournal.hematologylibrary.org)

"Hypoxia-inducible factor (HIF) pathway is crucial in mitigating the deleterious effects of oxygen deprivation. HIF-alpha is an essential component of the oxygen-sensing mechanisms and under normoxic conditions is targeted for degradation via hydroxylation by HIF-prolyl hydroxylases. Several HIF-prolyl hydroxylase inhibitors (PHI) induced erythropoietin (Epo) expression in vitro and in mice, with peak Epo expression ranging from 5.6 to 207 fold above control animals

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Demographic Histories and Patterns of Linkage Disequilibrium in Chinese and Indian Rhesus Macaques

addict submitted, created time 1 year 8 months (www.sciencemag.org)

To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four.

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