Histone H3-K56 Acetylation Is Catalyzed by Histone Chaperone-Dependent Complexes

julie submitted, created time 1 year 9 months (www.molecule.org)

"We show here that H3-K56 acetylation is catalyzed when Rtt109, a protein that lacks significant homology to known acetyltransferases, forms an active complex with either of two histone binding proteins, Asf1 or Vps75. Rtt109 binds to both these cofactors, but not to histones alone, forming enzyme complexes with kinetic parameters similar to those of known histone acetyltransferase (HAT) enzymes. "

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